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Description
Phospho-ATM (Ser1981) Recombinant Rabbit mAb (S-3396)Product Specification Host Rabbit Antigen ATM Synonyms Serine protein kinase ATM; Ataxia telangiectasia mutated (A T mutated) Location Nucleus Accession Q13315 Clone Number S 3396 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample Neocarzinostatin treated HCT 116 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | ATM |
| Synonyms | Serine-protein kinase ATM; Ataxia telangiectasia mutated (A-T mutated) |
| Location | Nucleus |
| Accession | Q13315 |
| Clone Number | S-3396 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | Neocarzinostatin treated HCT 116 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
Phospho-ATM (Ser1981) refers to the specific activated form of the Ataxia-Telangiectasia Mutated protein, phosphorylated at its serine 1981 residue. ATM is a key PI3K-related kinase that plays a central role in cellular signaling in response to DNA double-strand break damage. The Ser1981 site is located within the kinase domain of ATM. Its autophosphorylation is a hallmark early molecular event for ATM activation following DNA damage: when DNA double-strand breaks occur, ATM rapidly undergoes dimer dissociation and autophosphorylates the Ser1981 site, converting it into an active monomeric form. This phosphorylation event is crucial for the full activation of ATM kinase activity, enabling it to phosphorylate a series of critical downstream substrates (such as p53, CHK2, H2AX, etc.), thereby initiating key cellular responses including cell cycle checkpoint arrest, DNA repair, or apoptosis. Consequently, detecting Phospho-ATM (Ser1981) levels is widely used as a reliable biomarker for DNA damage response activation, holding significant application value in research areas such as tumor radiotherapy, genome stability assessment, and studies related to diseases like Ataxia-Telangiectasia.
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