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Ships within 48 hours · Estimated delivery Jul 12 - Jul 17
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Description
Phospho-p53 (Ser15) Recombinant Rabbit mAb (S-4249)Product Specification Host Rabbit Antigen Phospho p53 (Ser15) Synonyms Cellular tumor antigen p53; Antigen NY CO 13; Phosphoprotein p53; Tumor suppressor p53; P53; TP53 Location Nucleus Accession P04637 Clone Number S 4249 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms, Rt Positive Sample Etoposide treated L 929 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | Phospho-p53 (Ser15) |
| Synonyms | Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; P53; TP53 |
| Location | Nucleus |
| Accession | P04637 |
| Clone Number | S-4249 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms, Rt |
| Positive Sample | Etoposide treated L-929 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
Phospho-p53 (Ser15) is a critical biomarker of p53 activation, playing a key role in cellular responses to DNA damage and stress. When cells experience DNA damage, p53 is phosphorylated at serine 15, which stabilizes the protein and enhances its transcriptional activity. This phosphorylation event triggers a cascade of downstream effects, including cell cycle arrest, DNA repair, and apoptosis, depending on the severity of the damage. In senescent cells, phospho-p53 (Ser15) is often localized in the nucleus, where it interacts with other proteins such as FOXO4 to maintain the senescent state and prevent apoptosis. This regulatory mechanism is crucial for understanding the balance between cellular senescence and apoptosis, and it has significant implications for aging, cancer, and other age-related diseases.
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