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Description
Invivo Anti-Human PD-L1 (B7-H1) Recombinant mAbProduct Specification Host Mouse Antigen PD L1 Synonyms Programmed cell death 1 ligand 1; PD L1; PDCD1 ligand 1; Programmed death ligand 1; hPD L1; B7 homolog 1 (B7 H1); B7H1; PDCD1L1; PDCD1LG1; PDL1; CD274 Location Cell membrane Accession Q9NZQ7 Clone Number S 3805 Antibody Type Recombinant mAb Isotype Mouse IgG2b,k Application ELISA, WB, Functional Assay, in vitro PD L1 blockade Reactivity Hu Purification Protein A Concentration 5 mg ml Purity
Product Specification
| Host | Mouse |
| Antigen | PD-L1 |
| Synonyms | Programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; hPD-L1; B7 homolog 1 (B7-H1); B7H1; PDCD1L1; PDCD1LG1; PDL1; CD274 |
| Location | Cell membrane |
| Accession | Q9NZQ7 |
| Clone Number | S-3805 |
| Antibody Type | Recombinant mAb |
| Isotype | Mouse IgG2b,k |
| Application | ELISA, WB, Functional Assay, in vitro PD-L1 blockade |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
PD-L1 is a ~33 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily that functions as the key ligand for the inhibitory receptor PD-1 on T cells; upon IFN-γ–driven up-regulation on dendritic cells, macrophages, normal epithelia and many tumors, its engagement of PD-1 delivers a “stop” signal that blocks T-cell receptor signaling, suppressing proliferation, cytokine production and cytotoxic activity, thereby maintaining peripheral tolerance and preventing autoimmunity, but is exploited by cancers to evade immune destruction, making the PD-1/PD-L1 axis a central target for modern checkpoint-inhibitor immunotherapies.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
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