SKU: 86871450183

FITC Mouse Anti-Human CD161 Antibody (S-R581)

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Description

FITC Mouse Anti-Human CD161 Antibody (S-R581)Product Specification Host Mouse Antigen CD161 Synonyms Killer cell lectin like receptor subfamily B member 1; C type lectin domain family 5 member B; HNKR P1a (NKR P1A); Natural killer cell surface protein P1A; CLEC5B; NKRP1A; KLRB1 Location Membrane Accession Q12918 Clone Number S R581 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation FITC

Product Specification


Host Mouse
Antigen CD161
Synonyms Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a (NKR-P1A); Natural killer cell surface protein P1A; CLEC5B; NKRP1A; KLRB1
Location Membrane
Accession Q12918
Clone Number S-R581
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD161, also known as KLRB1 or NKRP1A, is a C-type lectin-like receptor primarily expressed on the surface of natural killer (NK) cells and a subset of T cells, including mucosal-associated invariant T (MAIT) cells and some CD8+ T cells. It is particularly enriched in immune cells located in mucosal sites such as the gut and liver. CD161 binds to its ligand, lectin-like transcript 1 (LLT1, also known as CLEC2D), and this interaction can have both inhibitory and costimulatory effects on immune cells. In the context of cancer immunotherapy, CD161 has been identified as a potential inhibitory receptor in glioma-infiltrating T cells. Its activation by CLEC2D on tumor or immunosuppressive cells can dampen T cell responses against cancer cells. Recent studies suggest that blocking the CD161-CLEC2D interaction may enhance T cell-mediated antitumor activity, making CD161 a promising target for cancer immunotherapy.

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SKU: 86871450183

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4.2 ★★★★★
Based on 11 reviews
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Product Reviews
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Verified Purchase
William Simonis
Lowell, US
★★★★★ 5
Refunding/giftcards. Thank you
They were nice enough to replace my vacuum even though the battery was defective. They usually don't cover batteries. So it was a great. But they were nice enough to give me a gift card for the whole amount. Thanks
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 9, 2026
U
Verified Purchase
Unkle Cleo
Birmingham, US
★★★★★ 5
Rather pricey.
Excellent vacuum, but I couldn’t justify the price knowing I have another Miele vacuum that works just as well as this one. My current Miele is 27 years old, works perfectly with all attachments, and only cost $20 several years ago. Hard to spend $500 for what I already own. However, if my current one fails, this will be its replacement.
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Reviewed in the United States on April 17, 2026
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Verified Purchase
M. P. Holmes
Natrona Heights, US
★★★★★ 4
Close to perfect
This model is among Miele's most recent ones, and benefits from a few small but significant improvements on that account. I'd say that all but one of the components are both beautifully made and beautifully conceived. The floor head initially strikes me as problematic, and for exactly the reason that's suggested by a great many customer reviews of Miele floor heads, which is that when attempting to vacuum even low pile carpet there is a dramatic tendency for the head to essentially glue itself to the carpet. The vacuum power needed to be set on the second lowest of four settings to be able to slide the head over the carpet at all, with either of the two settings of the floor head (carpet or bare floor). So it seems to me that Miele still hasn't figured out how to make a single, multi-purpose floor head, or at least one that isn't electrically powered with a motor in the head to rotate a brush. They do also have air-turbine powered head brushes and models with no rotating brush like the one that comes with the Guard M1. Many types in all. The noise level of this model is even lower than I had hoped and this is one feature that has been further improved - excellent. Also, note that you can replace the default exhaust filter with a separately purchased HEPA filter if that's what you want: 99.999% filtration of the bag plus the HEPA exhaust filter rather than 99.99% filtration of the bag plus the standard, thin, provided, cheaper exhaust filter. This could be important for either allergy issues or safety vacuuming where rodents have made a mess, which can be quite dangerous. Best to lightly spray with dilute chlorine bleach first. There are four exhaust filter grades to choose from. The most basic is the supplied one. Miele desperately needs to improve their documentation to help customers figure out all the variables in their very complex system of models and features. I like this machine a lot. I just need to figure out a better way to vacuum flat surfaces (floors) which are both bare and carpeted. We have almost no high pile or shag rugs (one), so I figured this basic head would be a good choice but I'm concerned that I might never choose to use it on our carpets. Not sure yet. Otherwise close to perfection. One other thing: it's too easy to attempt to insert the bag backwards and not realize it! Oh, one other thing - The cover door for the motor protection filter was stuck closed. It's supposed to snap open when pulling on the handle with modest force but a strong pull didn't to do the trick. There's a slight defect in the mold of one of the two parts where the latch functions. I eventually got it open and used a jeweler's file to very slightly take the edge off the stationary part and now it's fine, but a person could break the cover door trying to overpower the latch. This is a factory defect that's tiny but with potentially very large consequences.
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Reviewed in the United States on March 19, 2026
S
Verified Purchase
Sandy Mayfield
Battle Creek, US
★★★★★ 5
Best Investment Ever! A Vac-Mop!!!
Color: X40 Ultra/ L40 Ultra & P10 Pro /P50 Pro
These are replacement tools that fit our multipurpose vac/mop. This product is the most helpful and productive item we own. My daughter and I are free to do other things while Miss “B” is busy cleaning our floors! Such a backsaver! The floors are cleaner than manually sweeping and mopping them ourselves! It doesn’t get any better than that!
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Reviewed in the United States on April 21, 2026
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Verified Purchase
Brianna
Waukegan, US
★★★★★ 5
This is a Yes!
Color: X40 Ultra/ L40 Ultra & P10 Pro /P50 Pro
I needed to change out my Dreame vacuum accessories but didn’t want to pay the huge amount for the name brand kit, this works beautifully and fit perfectly. I cannot tell a difference and it lasts just as long as the original!
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Reviewed in the United States on April 8, 2026

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