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Description
S-RMab® ErbB2 Recombinant Rabbit mAb (SDT-069-57)Product Specification Host Rabbit Antigen ErbB2 Synonyms HER2, MLN19, NEU, NGL,CD340,ERBB2 Immunogen Synthetic Peptide Location Membrane Accession P04626 Clone Number SDT 069 57 Antibody Type Rabbit mAb Application WB, IHC P, ICC, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Rabbit |
| Antigen | ErbB2 |
| Synonyms | HER2, MLN19, NEU, NGL,CD340,ERBB2 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | P04626 |
| Clone Number | SDT-069-57 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:10000-1:50000 | |
| IHC-P | 1:1000 | |
| ICC | 1:500 | |
| IF | 1:500 |
Background
Receptor tyrosine-protein kinase erbB-2 is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other member of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.
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