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Description
PAX5 Recombinant rabbit mAb (SDT-120-73)Product Specification Host Rabbit Antigen PAX5 Synonyms Paired box protein Pax 5, B cell specific transcription factor, BSAP Immunogen Synthetic Peptide Location Nucleus Accession Q02548 Clone Number SDT 120 73 Antibody Type Rabbit mAb Application WB, IHC P, IP Reactivity Hu, Rt Purification Protein A Concentration 0. 5mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from
Product Specification
| Host | Rabbit |
| Antigen | PAX5 |
| Synonyms | Paired box protein Pax-5, B-cell-specific transcription factor, BSAP |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q02548 |
| Clone Number | SDT-120-73 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu, Rt |
| Purification | Protein A |
| Concentration | 0.5mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:100 | |
| IP | 1:25 |
Background
The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage 'inappropriate' genes and simultaneously activating B lineage–specific genes. This transcriptional reprogramming restricts the broad signaling capacity of uncommitted progenitors to the B cell pathway, regulates cell adhesion and migration, induces VH-DJH recombination, facilitates (pre-)B cell receptor signaling and promotes development to the mature B cell stage. Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B lymphopoiesis. PAX5 has also been implicated in human B cell malignancies, as it is deregulated by chromosomal translocations in a subset of acute lymphoblastic leukemias and non-Hodgkin lymphomas.
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