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Description
EGFR Recombinant Rabbit mAb (SDT-R110)Product Specification Host Rabbit Antigen EGFR Synonyms Epidermal growth factor receptor, ERBB1, HER1, c ErbB 1 Immunogen N A Location Endosome, Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane Accession P00533 Clone Number SDT R110 Antibody Type Rabbit mAb Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | EGFR |
| Synonyms | Epidermal growth factor receptor, ERBB1, HER1, c-ErbB-1 |
| Immunogen | N/A |
| Location | Endosome, Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane |
| Accession | P00533 |
| Clone Number | SDT-R110 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:500-1:2000 | null |
| ICC | 1:500 | null |
Background
The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intracellular region of the receptor. This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth, DNA synthesis and the expression of oncogenes such fos and jun [PMID: 9496384].
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