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Description
GFAP Recombinant Rabbit mAb (SDT-306-10)Product Specification Host Rabbit Antigen GFAP Synonyms Glial fibrillary acidic protein Immunogen Synthetic Peptide Location Cytoplasm Accession P14136 Clone Number SDT 306 10 Antibody Type Recombinant mAb Application WB, IHC P, IP, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | GFAP |
| Synonyms | Glial fibrillary acidic protein |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P14136 |
| Clone Number | SDT-306-10 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | |
| IHC-P | 1:1000 | |
| IP | 1:25 | |
| IF | 1:5000 |
Background
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease. Astrocytes assume a reactive phenotype in acute CNS trauma, ischemia, and in neurodegenerative diseases. This coincides with an upregulation and rearrangement of the IFs, which form a highly complex system composed of GFAP (10 isoforms), vimentin, synemin, and nestin [PMID: 25726916].
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