SKU: 42095108456

CALHM2 Recombinant Rabbit mAb (S-2671-146)

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Description

CALHM2 Recombinant Rabbit mAb (S-2671-146)Product Specification Host Rabbit Antigen CALHM2 Synonyms Calcium homeostasis modulator protein 2; Protein FAM26B; FAM26B Immunogen Synthetic Peptide Location Cell membrane Accession Q9HA72 Clone Number S 2671 146 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Mk Positive Sample U 2 OS, HeLa, U 87 MG, NIH 3T3, COS 7 Predicted Reactivity Bv Purification Protein A Concentration 2 mg ml Conjugation Unconjugated

Product Specification


Host Rabbit
Antigen CALHM2
Synonyms Calcium homeostasis modulator protein 2; Protein FAM26B; FAM26B
Immunogen Synthetic Peptide
Location Cell membrane
Accession Q9HA72
Clone Number S-2671-146
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Mk
Positive Sample U-2 OS, HeLa, U-87 MG, NIH/3T3, COS-7
Predicted Reactivity Bv
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Mk
IHC-P 1:50 Hu
ICC 1:50 Hu

Background

CALHM2 (Calcium Homeostasis Modulator 2) is a 323-amino-acid, four-pass transmembrane protein that oligomerizes into an undecameric, voltage-gated channel which—in addition to its originally described roles in taste-bud ATP release and neuronal excitability—has recently been shown to reside in the inner mitochondrial membrane where it functions as a Ca²⁺-inhibited import channel that translocates the ECHA subunit of the mitochondrial trifunctional protein into the matrix to enable fatty-acid β-oxidation, cristae integrity and normal respiratory metabolism, thereby coupling ion-channel gating to cellular energy supply and implicating CALHM2 in metabolic and neuropsychiatric disorders.

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SKU: 42095108456

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