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Description
Mouse Anti-Rat CD62L Antibody (S-R605)Product Specification Host Mouse Antigen CD62L Synonyms L selectin; CD62 antigen like family member L; Leukocyte adhesion molecule 1 (LAM 1); Leukocyte endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly 22); Lymphocyte surface MEL 14 antigen; Lnhr; Ly 22; Sell Location Cell membrane Accession P30836 Clone Number S R605 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample
Product Specification
| Host | Mouse |
| Antigen | CD62L |
| Synonyms | L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1 (LAM-1); Leukocyte-endothelial cell adhesion molecule 1 (LECAM1); Lymph node homing receptor; Lymphocyte antigen 22 (Ly-22); Lymphocyte surface MEL-14 antigen; Lnhr; Ly-22; Sell |
| Location | Cell membrane |
| Accession | P30836 |
| Clone Number | S-R605 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | Lewis Rat splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Rt |
Background
CD62L, also known as L-selectin, is a type-I transmembrane glycoprotein and a member of the selectin family of adhesion molecules. It is expressed on most circulating leukocytes, including T cells, B cells, and neutrophils. CD62L plays a crucial role in leukocyte adhesion and migration, particularly in the process of lymphocyte homing to secondary lymphoid organs such as lymph nodes. It mediates the initial rolling of leukocytes on endothelial cells, which is a key step in the recruitment of immune cells to sites of inflammation. Additionally, CD62L is a marker for central memory T cells, which have the ability to rapidly respond to antigen re-exposure. Its expression levels can also indicate the differentiation state of certain immune cells and is involved in various immune responses.
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Exchange/Return Notes
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