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Description
S-RMab® CD117 Recombinant Rabbit mAb,PBS Only (SDT-125-51)Product Specification Host Rabbit Antigen CD117 Synonyms Piebald trait protein (PBT), Proto oncogene c Kit, Tyrosine protein kinase Kit, p145 c kit, v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog, KIT, SCFR Immunogen Synthetic Peptide Location Cytoplasm, Membrane Accession P10721 Clone Number SDT 125 51 Antibody Type Rabbit mAb Application IHC P, IF, ICFCM Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | CD117 |
| Synonyms | Piebald trait protein (PBT), Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, KIT, SCFR |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Membrane |
| Accession | P10721 |
| Clone Number | SDT-125-51 |
| Antibody Type | Rabbit mAb |
| Application | IHC-P, IF, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | |
| ICFCM | 1:250 | |
| IF | 1:200 |
Background
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor , also known as "steel factor" or "c-kit ligand" and expressed on the surface of hematopoietic stem cells as well as other cell types. When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. After activation, the receptor is ubiquitinated to mark it for transport to a lysosome and eventual destruction. Signaling through KIT plays a role in cell survival, proliferation, and differentiation. For instance, KIT signaling is required for melanocyte survival, and it is also involved in haematopoiesis and gametogenesis.
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