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Description
MYPT1 Recombinant Rabbit mAb (S-1298-106)Product Specification Host Rabbit Antigen MYPT1 Synonyms Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase targeting subunit 1 (Myosin phosphatase target subunit 1); Protein phosphatase myosin binding subunit; PPP1R12A; MBS Immunogen Recombinant Protein Accession O14974 Clone Number S 1298 106 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample HeLa, Caco 2, NIH 3T3 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | MYPT1 |
| Synonyms | Protein phosphatase 1 regulatory subunit 12A; Myosin phosphatase-targeting subunit 1 (Myosin phosphatase target subunit 1); Protein phosphatase myosin-binding subunit; PPP1R12A; MBS |
| Immunogen | Recombinant Protein |
| Accession | O14974 |
| Clone Number | S-1298-106 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, Caco-2, NIH/3T3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
MYPT1, or Myosin Phosphatase Targeting Subunit 1, is a regulatory subunit that binds to the catalytic subunit of protein phosphatase 1 (PP1) to form the myosin phosphatase (MP) complex. This complex is crucial for the dephosphorylation of myosin light chains, which regulates muscle contraction and relaxation. MYPT1 acts as a tumor suppressor in various cancers. It inhibits tumor progression by regulating gene expression and modulating the activity of oncogenic pathways. For instance, in prostate cancer, reduced MYPT1 expression is associated with increased tumor angiogenesis and poor patient prognosis. Similarly, in non-small cell lung cancer, MYPT1 regulated by miR-19b-3p inhibits tumor progression.
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