HERBAL MAGIC - WM-4000 Ultra

HERBAL MAGIC - WM-4000 UltraNPN: 80013740 Helps to maintain the body's ability to metabolize nutrients. This can be useful for those who would like help improving their metabolism or for those who may benefit from support for blood glucose metabolism, such as those with unsteady energy and hunger levels throughout the day. WM 4000 Ultra is a natural health product that combines B vitamins, magnesium, and chromium to support clients as they work to lose weight. This product helps

NPN: 80013740

Helps to maintain the body's ability to metabolize nutrients.

This can be useful for those who would like help improving their metabolism or for those who may benefit from support for blood glucose metabolism, such as those with unsteady energy and hunger levels throughout the day.

WM-4000 Ultra is a natural health product that combines B vitamins, magnesium, and chromium to support clients as they work to lose weight. This product helps in energy metabolism, and also supports healthy blood glucose and muscle function.

PRODUCT MONOGRAPH FOR HERBAL MAGIC
WM4000^TM Ultra      NPN 80013740

GENERAL INFORMATION
Herbal Magic’s WM 4000TM Ultra is designed to complement Herbal Magic’s weight management programs. The formulation of WM 4000 TM Ultra is designed to help support healthy glucose metabolism. Together with a reduced diet, the combination of ingredients in this formula provides support for safe, natural and successful weight management.

RECOMMENDED USES
Primary Uses: A factor in the maintenance of good health; helps in energy metabolism; helps to maintain the body's ability to metabolize nutrients; provides support for healthy glucose metabolism; helps to maintain proper muscle function; helps in the development and maintenance of bones and teeth; helps in tissue formation.

MECHANISM OF ACTION
Research Suggests
Chromium
Chromium is an essential trace element and chromium (III) is the form of chromium found in supplements and in food. Chromium has been shown to be useful in its ability to support insulin, thereby assisting in healthy glucose metabolism. It is thought that chromium potentiates the action of insulin by increasing receptor numbers and increasing insulin binding to cells.¹

Chromium is widely used for weight loss, to increase muscle mass and fat-free mass, and decrease body fat. Results from scientific investigations have indicated that chromium supplementation increases muscle gain and fat loss associated with exercise and improves glucose metabolism and the serum lipid profile in patients with or without diabetes.^2,3,4,5,6,7

Pantothenic acid
Pantothenic acid is intermediately involved in the metabolism of carbohydrates, proteins and lipids and is a component of coenzyme A, a molecule necessary for numerous vital chemical reactions to occur in cells.^1,8

Magnesium
Magnesium is critical to normal human homeostasis playing many roles in energy metabolism: as an enzyme cofactor, in electrolyte balance, and in the maintenance of the properties of various cell membranes. As one of the four most abundant cations in the body, magnesium is present in more than 300 enzymatic systems.^9,10 The range of pathologies associated with magnesium deficiency is staggering. Magnesium helps the body to metabolize carbohydrates, fats and proteins.^13,9

Thiamine
Thiamine is a water soluble vitamin that is essential in metabolic energy production and the metabolism of fats, carbohydrates and proteins. Since humans are unable to synthesize thiamine, this vitamin must be obtained from exogenous sources. The body requires more thiamine in cases of increased metabolic demand such as weight loss. In such cases, the supply may be rapidly depleted so it is important to ensure frequent and adequate supply of this essential vitamin.^11,12

RECOMMENDED DOSAGE
Adults: For oral use only. Take 2 capsules 3 times daily or as directed by your health care practitioner.

CAUTIONS AND WARNINGS
For adult use only.

FORMULATION
Medicinal Ingredients:
Chromium (Chromium chloride)…………………………………15 mcg
Pantothenic acid (Calcium-D-pantothenate)…………………0.1 mg
Magnesium (Magnesium Oxide) ………………………………….7.5mg
Thiamine (Thiamine mononitrate)………………………………2.5 mg

Non-medicinal Ingredients:
Hypromellose, magnesium stearate and microcrystalline cellulose.

REFERENCES
¹ Cefalu WT, Frank B. Role of Chromium in Human Health and in Diabetes. Diabetes Care. 2004;27(11):2741.
² Potter JF, Levin P, Anderson RA, et al. Glucose metabolism in glucose-intolerant older people during chromium supplementation. Metabolism. 1985;34:199 –204.
³ Ghosh D, Bhattacharya B, Mukherjee B, et al. Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem. 2002;13:690–697.
⁴ Bahijri SM, Mufti AM. Beneficial effects of chromium in people with type 2 diabetes, and urinary chromium response to glucose load as a possible indicator of status. Biol Trace Elem Res. 2002;85:97–10.
⁵ Anderson R. Chromium as an essential nutrient for humans. Reg Toxicol Pharmacol. 1997;26:S35–S41.
⁶ Roeback JR Jr, Hla KM, Chambless LE, Fletcher RH. Effects of chromium supplementation on serum high-density lipoprotein cholesterol levels in men taking beta-blockers a randomized, controlled trial. Ann Intern Med. 1991;115:917–924.
⁷ Crawford V, Scheckenbach R, Preuss HG. Effects of niacin-bound chromium supplementation on body composition in overweight African-American women. Diabetes Obes Metab. 1999;1:331–337
⁸ Health Canada. Natural Health Products Directorate. Product Monographs. Pantothenic Acid 2007. Available at: www.hc-sc.gc.ca Accessed Jan 4, 2011.
⁹ Health Canada. Natural Health Products Directorate. Product Monographs. Magnesium. 2007. Available at: www.hc-sc.gc.ca Accessed Jan 5, 2011.
¹⁰ Fox C, Ramsoomair D, Carter C. Magnesium: Its Proven and Potential Clinical Significance. South Med J. 2001;94(12).
¹¹ Gagnolf M, Czerniecki J, Radermecker M. Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells. PLoS ONE. 2010;5:10,e13616.
¹² Singleton CK, Martin PR. Molecular mechanisms of thiamine utilization. Curr Mol Med. 2001 May;1(2):197-207.